Dietary flavonoid research compound · Fact sheet
Apigenin
Apigenin is a flavonoid found in foods and chamomile. Human absorption research does not establish that purified apigenin treats insomnia; studies of whole chamomile cannot be assigned automatically to one constituent.
What is Apigenin?
The free compound and its glycosides have different absorption and metabolism.
A tea or plant extract contains multiple substances and is not equivalent to an isolated apigenin capsule.
Benefits & claims
Interest in Apigenin spans cognition and sleep, aging and energy. Study findings apply to the named formulation and population.
What the evidence supports
- Human research documents absorption and metabolism, with poor absorption of free apigenin in the tested setting.
- Cellular inflammatory-signaling findings do not establish a sleep or cancer treatment.
- There is no verified established human insomnia amount or frequency for purified apigenin in these sources.
Research areas
- Formulation-specific human outcomes
- Mechanistic research
Dosage & frequency
No established human regimenThe reviewed sources do not establish a human treatment amount or frequency for Apigenin. Animal and laboratory exposures are not human regimens.
How to read these amounts
An approved regimen belongs to a specific product, indication, and population. A study regimen describes what researchers tested; it does not establish a prescription or a safe self-use protocol. Products, routes, and formulations are not interchangeable. A prescriber uses the full label and individual clinical circumstances.
Personal accounts may describe amounts, schedules and outcomes beyond clinical research. They do not establish a regimen. Read the reported experiences
Formulations, interactions & practical context
- Identity and pharmacology
- The free compound and its glycosides have different absorption and metabolism.
Formulation differences
- A tea or plant extract contains multiple substances and is not equivalent to an isolated apigenin capsule.
Interactions & precautions
- The reviewed sources do not establish a comprehensive human interaction profile for this exact substance or combination.
What is still unresolved
- Reproducibility in larger independent trials
- Long-term outcomes and adverse effects
- Equivalence of different preparations and interaction profiles
Side effects & risks
- Human long-term safety and drug interactions at concentrated supplement exposures remain insufficiently defined.
- Food exposure does not establish safety of all isolated-compound amounts or formulations.
This is a summary of the cited evidence, not a complete product label. A lack of human safety data does not establish safety.
Clinical research
Limited or unclear evidenceA human pharmacokinetic study found major food-matrix and metabolite differences. Mechanistic anti-inflammatory work was performed in cells rather than clinical insomnia trials.
Studies
Human apigenin/glycoside absorption study; not a sleep-efficacy trial.
Inflammatory signaling in mouse macrophages.
Personal experiences
Reports describe what someone noticed. They cannot establish cause, typical results, or how often a side effect happens. Amounts and schedules describe the individual account, not an effective or safe dose. Product identity and strength may be unverified, and missing details are left explicit.
No attributable personal accounts were found in the sources reviewed.
Approval status
No FDA-approved Apigenin drug indication is established for the supplement uses discussed here. Supplement availability is not FDA approval of efficacy or safety.
No FDA-approved product for this entry
Approval covers the labeled product, use and population. A trial phase does not establish success; a stopped program is not ongoing research.
Open questions
- Reproducibility in larger independent trials
- Long-term outcomes and adverse effects
- Equivalence of different preparations and interaction profiles
Summary
There is no verified established human insomnia amount or frequency for purified apigenin in these sources.
Sources
Medical evidence and regulatory sources are listed here. Personal reports are linked separately in the experiences section.
- pubmedAbsorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults.
Human apigenin/glycoside absorption study; not a sleep-efficacy trial.
- pubmedSuppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.
Inflammatory signaling in mouse macrophages.
- fdaFDA: what approval means for supplements
Dietary supplements are not approved by FDA for safety and effectiveness before marketing.