FDA approved for specific uses
Semaglutide
A GLP-1 medicine with FDA-approved products for type 2 diabetes and chronic weight management.
Strong human evidence for approved uses
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Popular fact sheets
FDA approved for specific uses
Tirzepatide
A dual GIP/GLP-1 receptor agonist approved for specific metabolic and sleep-apnea uses.
Strong human evidence for approved uses
Read fact sheet In clinical trials
Retatrutide
An investigational triple-receptor agonist in Phase 3 clinical trials.
Early human evidence
Read fact sheet FDA approved for specific uses
Liraglutide
An established GLP-1 medicine approved for specific diabetes and weight-management uses.
Strong human evidence for approved uses
Read fact sheet FDA approved for specific uses
Tesamorelin
A growth hormone-releasing factor analog approved for a narrow HIV-related indication.
Strong human evidence for approved uses
Read fact sheet Discontinued
Sermorelin
A growth hormone-releasing hormone analog whose former FDA-approved product was discontinued.
Limited or unclear evidence
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Similar search terms. Very different evidence.
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GLP-1 peptides compared in plain English
How semaglutide, tirzepatide, liraglutide, and investigational retatrutide differ in targets, evidence, and approval status.
Peptides for weight management: approved versus experimental
A status-first look at approved medicines and experimental peptides discussed for body weight.
Peptides for recovery: what evidence exists?
What the evidence really says about BPC-157, thymosin beta-4, CJC-1295, and ipamorelin for injury recovery.
Research updates
Signal, not spectacle
FDA & regulatory
FDA approves tirzepatide for obstructive sleep apnea in adults with obesity
What the Zepbound approval covers, what supported it, and what it does not mean.
Clinical trialsRetatrutide outcomes program advances through Phase 3
What large ongoing trials are designed to answer—and why retatrutide remains investigational.
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