Alpha-ketoglutarate
A central metabolic intermediate with mouse healthspan findings and unfinished human geroscience questions.
Healthy agingMetabolic healthMitochondrial health
Related molecule
In clinical trialsMostly animal or lab researchOpen Status database
A single scan of status, evidence, and entity type.
This linkable reference asset pulls from the typed fact-sheet library so each row points back to a full source-backed page.
Status coverage
FDA approved for specific uses18
In clinical trials10
Preclinical research2
Not FDA approved16
Discontinued2
Evidence coverage
Strong human evidence for approved uses17
Moderate human evidence8
Early human evidence11
Mostly animal or lab research7
Limited or unclear evidence5
NameTypeStatusEvidencePage
BPC-157
An experimental synthetic peptide popular online despite very limited reliable human evidence.
recoveryexperimental
Peptide
Not FDA approvedMostly animal or lab researchOpen Bremelanotide
A melanocortin-receptor peptide approved for a narrowly defined sexual-desire disorder.
sexual healthmelanocortinapproved medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Cagrilintide
An investigational long-acting amylin analog studied alone and with semaglutide for obesity and type 2 diabetes.
amylin analogweight researchmetabolic research
Peptide
In clinical trialsModerate human evidenceOpen CJC-1295
An unapproved growth hormone-releasing hormone analog with limited human data.
growth hormone pathwayexperimental
Peptide
Not FDA approvedEarly human evidenceOpen Creatine
A well-studied performance supplement with credible muscle evidence and a less certain cognitive-aging frontier.
Muscle and performanceCognition and brainHealthy aging
Related molecule
Not FDA approvedModerate human evidenceOpen Dasatinib plus quercetin
An experimental senolytic pairing that combines a serious cancer medicine with a flavonoid.
Healthy agingCellular senescenceLung research
Related molecule
In clinical trialsEarly human evidenceOpen Elamipretide
A mitochondria-targeting peptide with an accelerated FDA approval for a narrow Barth syndrome indication.
mitochondrial researchrare diseasemuscle function
Peptide
FDA approved for specific usesModerate human evidenceOpen Exenatide
An FDA-approved diabetes peptide whose promising Phase 2 Parkinson signal failed in a larger Phase 3 trial.
GLP-1 receptor agonistdiabetesParkinson research
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Fisetin
A plant flavonoid with striking mouse senolytic findings but no proven human longevity or frailty benefit.
Healthy agingCellular senescenceHeart and vascular
Related molecule
In clinical trialsMostly animal or lab researchOpen GHK-Cu
A copper-binding tripeptide used in cosmetic research, with mostly laboratory and animal wound-healing evidence.
skin researchwound researchhair research
Peptide
Not FDA approvedMostly animal or lab researchOpen GHRP-2
An unapproved ghrelin-receptor agonist that raises growth hormone and appetite without proven muscle-building outcomes.
growth hormone pathwaymuscle claimsappetite research
Peptide
Not FDA approvedEarly human evidenceOpen Humanin
A mitochondrial-derived peptide studied for cell survival, neuroprotection, metabolism, and aging mostly in preclinical work.
mitochondrial researchcognitive researchaging biology
Peptide
Preclinical researchMostly animal or lab researchOpen Ipamorelin
An unapproved growth hormone secretagogue with limited clinical evidence and FDA-identified concerns.
growth hormone pathwayexperimental
Peptide
Not FDA approvedEarly human evidenceOpen Ketone esters and beta-hydroxybutyrate
Compounds that raise circulating ketones reliably but have not established cognitive or healthy-aging benefit.
Cognition and brainHealthy agingMetabolic health
Related molecule
In clinical trialsEarly human evidenceOpen Kisspeptin
A reproductive signaling peptide studied in fertility, hormone release, and brain responses.
reproductive healthfertility researchneuroendocrine research
Peptide
In clinical trialsEarly human evidenceOpen Linaclotide
A minimally absorbed peptide medicine approved for several constipation disorders in defined adult and pediatric populations.
digestive healthconstipationIBS
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Liraglutide
An established GLP-1 medicine approved for specific diabetes and weight-management uses.
GLP-1metabolic healthapproved medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Lixisenatide
A discontinued U.S. GLP-1 product with established diabetes evidence and an encouraging but unconfirmed Parkinson trial.
GLP-1 receptor agonistdiabetesParkinson research
Peptide
DiscontinuedModerate human evidenceOpen Metformin
A foundational diabetes medicine being studied in geroscience, without an approved anti-aging use.
Metabolic healthHealthy agingMuscle and performance
Related molecule
FDA approved for specific usesStrong human evidence for approved usesOpen MOTS-c
A mitochondrial-derived peptide with intriguing metabolic and exercise biology but no proven human therapy.
mitochondrial researchmetabolic researchexercise biology
Peptide
Preclinical researchMostly animal or lab researchOpen NAD+
A central cellular coenzyme with legitimate biology but little clinical-outcomes evidence for wellness infusions.
Healthy agingMitochondrial healthCognition and brain
Related molecule
Not FDA approvedLimited or unclear evidenceOpen Nicotinamide mononucleotide
An NAD+ precursor with small human trials and unresolved real-world clinical value.
Healthy agingMitochondrial healthMetabolic health
Related molecule
Not FDA approvedEarly human evidenceOpen Nicotinamide riboside
An NAD+ precursor that reliably changes biomarkers but has not shown a consistent anti-aging or cognitive benefit.
Healthy agingMitochondrial healthCognition and brain
Related molecule
Not FDA approvedEarly human evidenceOpen Oxytocin
A natural peptide hormone with approved obstetric products and unproven intranasal cognitive or social uses.
neuropsychiatric researchsocial cognitionreproductive health
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Pemvidutide
An investigational glucagon/GLP-1 dual agonist in mid-stage research for MASH, liver fat, and obesity.
dual receptor agonistliver researchweight research
Peptide
In clinical trialsEarly human evidenceOpen Plecanatide
An FDA-approved gut-signaling peptide for chronic idiopathic constipation and IBS with constipation in adults.
digestive healthconstipationIBS
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Pramlintide
An FDA-approved amylin analog for selected insulin-treated diabetes patients, with unapproved weight-management research.
amylin analogdiabetesweight research
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Retatrutide
An investigational triple-receptor agonist in Phase 3 clinical trials.
GLP-1GIPglucagon
Peptide
In clinical trialsModerate human evidenceOpen Rusfertide
An investigational hepcidin-mimetic peptide under FDA priority review for polycythemia vera.
hematologyiron regulationlate-stage research
Peptide
In clinical trialsModerate human evidenceOpen Selank
An unapproved synthetic heptapeptide studied for anxiety, with a thin and uncertain human evidence base.
anxiety researchcognitive researchnootropic claims
Peptide
Not FDA approvedLimited or unclear evidenceOpen Semaglutide
A GLP-1 medicine with FDA-approved products for type 2 diabetes and chronic weight management.
GLP-1metabolic healthapproved medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Semax
An unapproved neuroactive heptapeptide with old, small human studies and substantial evidence gaps.
cognitive researchneuroprotectionnootropic claims
Peptide
Not FDA approvedLimited or unclear evidenceOpen Sermorelin
A growth hormone-releasing hormone analog whose former FDA-approved product was discontinued.
growth hormone pathwaydiscontinued medicine
Peptide
DiscontinuedLimited or unclear evidenceOpen Setmelanotide
An MC4-receptor peptide medicine approved for obesity caused by specific rare genetic conditions.
metabolic healthrare genetic obesitymelanocortin
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Sirolimus
An FDA-approved immunosuppressant with serious risks and unproven longevity use in healthy people.
Healthy agingImmune and infectionTransplant medicine
Related molecule
FDA approved for specific usesStrong human evidence for approved usesOpen Spermidine
A food-derived polyamine linked to autophagy biology, with a negative phase 2 cognitive primary outcome.
Healthy agingCognition and brainCellular maintenance
Related molecule
Not FDA approvedEarly human evidenceOpen Survodutide
An investigational glucagon/GLP-1 dual agonist in Phase 3 research for obesity and metabolic liver disease.
dual receptor agonistweight researchliver research
Peptide
In clinical trialsModerate human evidenceOpen Taurine
A common nutrient-related molecule whose animal longevity story is challenged by newer human aging data.
Healthy agingMuscle and performanceHeart and vascular
Related molecule
Not FDA approvedLimited or unclear evidenceOpen Teduglutide
An FDA-approved GLP-2 analog that improves intestinal absorption in short bowel syndrome dependent on parenteral support.
digestive healthintestinal failurerare disease
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Tesamorelin
A growth hormone-releasing factor analog approved for a narrow HIV-related indication.
growth hormone pathwaymetabolic healthapproved medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Thymosin alpha-1
An immune-modulating peptide used in some countries but not FDA approved for any U.S. indication.
immune researchinfectious-disease researchcritical-care research
Peptide
Not FDA approvedModerate human evidenceOpen Thymosin beta-4
A naturally occurring peptide studied in tissue repair; marketed fragments are not FDA approved.
recoverytissue repairexperimental
Peptide
Not FDA approvedMostly animal or lab researchOpen Tirzepatide
A dual GIP/GLP-1 receptor agonist approved for specific metabolic and sleep-apnea uses.
GLP-1GIPmetabolic health
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Trofinetide
An FDA-approved synthetic peptide analog for Rett syndrome with modest trial benefits and frequent gastrointestinal adverse effects.
neurodevelopmentrare diseaseapproved medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Urolithin A
A mitophagy-related metabolite with human biomarker and muscle-endurance signals but no approved disease use.
Mitochondrial healthMuscle and performanceHealthy aging
Related molecule
Not FDA approvedEarly human evidenceOpen Vosoritide
A C-type natriuretic peptide analog approved to increase growth in children with achondroplasia.
bone growthrare diseasepediatric medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen Ziconotide
A cone-snail-inspired peptide medicine approved for severe chronic pain under specialist care.
pain researchneuroscienceapproved medicine
Peptide
FDA approved for specific usesStrong human evidence for approved usesOpen