Pineal-derived peptide extract · Fact sheet
Epithalamin
Also known as Epithalamine
Epithalamin is a pineal-derived peptide preparation studied in animal aging models. It is different from the synthetic tetrapeptide epitalon; findings for the extract do not establish a human epitalon regimen or longer human life.
What is Epithalamin?
A tissue-derived preparation is a mixture, not one defined four-amino-acid molecule.
Melatonin, epithalamin and epitalon are related to pineal research but are different interventions.
Benefits & claims
Interest centers on aging and cellular function, brain function and sleep. Biological activity does not itself establish a clinical treatment.
What the evidence supports
- Animal studies reported lifespan or melatonin-related changes under particular experimental conditions.
- Some lifespan outcomes varied by species or strain.
- These findings do not establish clinical anti-aging efficacy or a defined human treatment schedule.
Research areas
- Experimental tissue and cellular responses
- Formulation-specific outcomes
Dosage & frequency
No established human regimenThe reviewed sources do not establish a human treatment amount or frequency for Epithalamin. Animal and laboratory exposures are not human regimens.
How to read these amounts
An approved regimen belongs to a specific product, indication, and population. A study regimen describes what researchers tested; it does not establish a prescription or a safe self-use protocol. Products, routes, and formulations are not interchangeable. A prescriber uses the full label and individual clinical circumstances.
Personal accounts may describe amounts, schedules and outcomes beyond clinical research. They do not establish a regimen. Read the reported experiences
Formulations, interactions & practical context
- Identity and pharmacology
- A tissue-derived preparation is a mixture, not one defined four-amino-acid molecule.
Formulation differences
- Melatonin, epithalamin and epitalon are related to pineal research but are different interventions.
Interactions & precautions
- The reviewed sources do not establish a comprehensive human interaction profile for this exact substance or combination.
What is still unresolved
- Controlled human clinical outcomes for the exact substance
- Human exposure, pharmacokinetics and repeated-use safety
- Independent replication and formulation equivalence
Side effects & risks
- Long-term human safety, composition consistency and immune reactions are not established by animal lifespan work.
- An extract cannot inherit the pharmacokinetics or safety of melatonin or a synthetic peptide.
This is a summary of the cited evidence, not a complete product label. A lack of human safety data does not establish safety.
Clinical research
Mostly animal or lab researchThe cited primary studies involve rats, mice or fruit flies and examine lifespan, melatonin or oxidation-related outcomes.
Studies
Old-rat lifespan and melatonin investigation.
Fruit-fly, mouse and rat lifespan study.
Rat acute-hypoxia oxidative-marker experiment.
Personal experiences
Reports describe what someone noticed. They cannot establish cause, typical results, or how often a side effect happens. Amounts and schedules describe the individual account, not an effective or safe dose. Product identity and strength may be unverified, and missing details are left explicit.
No attributable personal accounts were found in the sources reviewed.
Approval status
Epithalamin has no FDA-approved therapeutic product. The cited experiments or cosmetic uses do not establish an approved human treatment.
No FDA-approved product for this entry
Approval covers the labeled product, use and population. A trial phase does not establish success; a stopped program is not ongoing research.
- Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats.
- Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats.
- Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia.
Open questions
- Controlled human clinical outcomes for the exact substance
- Human exposure, pharmacokinetics and repeated-use safety
- Independent replication and formulation equivalence
Summary
These findings do not establish clinical anti-aging efficacy or a defined human treatment schedule.
Sources
Medical evidence and regulatory sources are listed here. Personal reports are linked separately in the experiences section.
- pubmedEffect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats.
Old-rat lifespan and melatonin investigation.
- pubmedPineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats.
Fruit-fly, mouse and rat lifespan study.
- pubmedEffects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia.
Rat acute-hypoxia oxidative-marker experiment.