Peptides & compounds

An experimental NNMT inhibitor studied for metabolic effects in mice.

5A1MQ · 5-amino-1-methylquinolinium

A metabolic intermediate studied for aging, mainly in mice.

AKG · 2-oxoglutarate · calcium alpha-ketoglutarate · Ca-AKG

An antioxidant studied for diabetic nerve symptoms, with mixed results across trial durations and endpoints.

ALA · Thioctic acid

A growth-hormone fragment studied for obesity, without an FDA-approved weight-loss use.

AOD9604 · Tyr-hGH 177–191

A botanical extract studied for stress and sleep, with formulation differences and reported liver-safety concerns.

Withania somnifera

A plant alkaloid studied for glucose and lipid changes, with uncertain weight-loss benefits and important interactions.

An experimental peptide with very limited reliable human evidence.

Body Protection Compound 157

A melanocortin-receptor peptide approved for a narrowly defined sexual-desire disorder.

Vyleesi · PT-141

An investigational long-acting amylin analog studied alone and with semaglutide for obesity and type 2 diabetes.

AM833 · long-acting amylin analog

An unapproved growth hormone-releasing hormone analog with limited human data.

CJC-1295 DAC

A supplement with established exercise evidence and less certain cognitive benefits.

creatine monohydrate · methylguanidineacetic acid

An experimental senolytic combination of a cancer medicine and a flavonoid.

D+Q · DQ senolytic combination

A cognition research compound with preclinical HGF/c-Met findings and major human safety gaps.

PNB-0408 · Dihexa acetate

A sleep research peptide with small, inconsistent older human studies.

Delta sleep-inducing peptide · Emideltide

A mitochondria-targeting peptide with an accelerated FDA approval for a narrow Barth syndrome indication.

Forzinity · SS-31 · MTP-131 · Bendavia

An oral macrocyclic peptide approved as Lipfendra to lower LDL cholesterol in specified adult populations.

Enlicitide decanoate · MK-0616 · Lipfendra

An experimental peptide associated with telomere and aging claims, based largely on laboratory evidence.

Epithalon · AEDG

An approved diabetes medicine whose larger Parkinson trial did not confirm earlier findings.

Byetta · Bydureon · exendin-4

A flavonoid with mouse senolytic findings but no proven human longevity benefit.

senolytic flavonoid · dietary fisetin

A copper-binding tripeptide used in cosmetic research, with mostly laboratory and animal wound-healing evidence.

copper tripeptide-1 · copper peptide GHK-Cu

An unapproved ghrelin-receptor agonist that raises growth hormone and appetite without proven muscle-building outcomes.

growth hormone-releasing peptide-2 · pralmorelin

A peptide that releases growth hormone, with limited evidence for meaningful recovery outcomes.

Growth hormone-releasing peptide-6

A tripeptide antioxidant with small human biomarker and skin-pigmentation studies; broad wellness benefits are unproven.

GSH · Reduced glutathione

An amino acid with small sleep studies and broader metabolic research; clinical benefits remain uncertain.

An experimental growth-hormone secretagogue with hormone and sleep effects in small studies.

Examorelin

A mitochondrial-derived peptide studied mainly in cells and animals.

HN · MT-RNR2 peptide · S14G-humanin (experimental analog)

A non-peptide growth-hormone secretagogue with lean-mass findings, glucose effects, and a heart-failure safety signal.

MK-677 · MK-0677 · Ibutamoren mesylate

An unapproved growth hormone secretagogue with limited clinical evidence and FDA-identified concerns.

ipamorelin acetate

Compounds that raise circulating ketones reliably but have not established cognitive or healthy-aging benefit.

BHB · beta-hydroxybutyrate · exogenous ketones · ketone monoester

A reproductive signaling peptide studied in fertility, hormone release, and brain responses.

kisspeptin-54 · kisspeptin-10 · metastin

A short peptide with anti-inflammatory findings in cells and mice, without established human benefits.

Lys-Pro-Val

A tea-derived amino acid studied for stress, attention and sleep, with small and mixed human trials.

Theanine

A minimally absorbed peptide medicine approved for several constipation disorders in defined adult and pediatric populations.

Linzess · guanylate cyclase-C agonist

An established GLP-1 medicine approved for specific diabetes and weight-management uses.

Victoza · Saxenda

A discontinued U.S. GLP-1 product with established diabetes evidence and an encouraging but unconfirmed Parkinson trial.

Adlyxin · Lyxumia · lixisenatide acetate

An unapproved melanocortin peptide associated with tanning and sexual effects, with important safety signals.

Melanotan-2 · MT-II · MT2

A sleep-timing hormone studied for circadian sleep problems; effects depend on the sleep condition and formulation.

A diabetes medicine being studied for aging, without an approved anti-aging use.

Glucophage · metformin hydrochloride

A dye and medicine approved for acquired methemoglobinemia; wellness claims have very different evidence and risks.

Methylthioninium chloride · ProvayBlue

A mitochondrial-derived peptide studied for metabolism and exercise, without a proven human therapy.

MOTS-c peptide · mitochondrial ORF of 12S rRNA type-c

An acetaminophen antidote with separate research into psychiatric symptoms and antioxidant biology.

NAC · Acetylcysteine

A cellular coenzyme with limited clinical evidence for wellness infusions.

nicotinamide adenine dinucleotide · NAD

An NAD+ precursor with small human trials and unresolved real-world clinical value.

NMN · beta-NMN

An NAD+ precursor that reliably changes biomarkers but has not shown a consistent anti-aging or cognitive benefit.

NR · niagen

An oral, non-peptide GLP-1 medicine approved as Foundayo for a defined adult weight-management indication.

Foundayo · LY3502970

A natural peptide hormone with approved obstetric products and unproven intranasal cognitive or social uses.

Pitocin · synthetic oxytocin

An investigational glucagon/GLP-1 dual agonist in mid-stage research for MASH, liver fat, and obesity.

ALT-801

An FDA-approved gut-signaling peptide for chronic idiopathic constipation and IBS with constipation in adults.

Trulance · uroguanylin analog

An FDA-approved amylin analog for selected insulin-treated diabetes patients, with unapproved weight-management research.

Symlin · pramlintide acetate

A flavonoid studied for blood pressure and inflammation; findings do not establish general senolytic or longevity benefits.

A plant polyphenol with mixed human metabolic findings and no established life-extension benefit.

Trans-resveratrol

An investigational triple-receptor agonist in Phase 3 clinical trials.

LY3437943

A hepcidin-mimetic peptide approved as Mimrylo for erythrocytosis in adults with polycythemia vera.

PTG-300 · Mimrylo

An unapproved synthetic heptapeptide studied for anxiety, with a thin and uncertain human evidence base.

Selank acetate · TP-7

A GLP-1 medicine with FDA-approved products for type 2 diabetes and chronic weight management.

Ozempic · Wegovy · Rybelsus

An unapproved neuroactive heptapeptide with old, small human studies and substantial evidence gaps.

Semax heptapeptide · ACTH(4-7)-Pro-Gly-Pro

A growth hormone-releasing hormone analog whose former FDA-approved product was discontinued.

Geref · sermorelin acetate

An MC4-receptor peptide medicine approved for obesity caused by specific rare genetic conditions.

Imcivree · RM-493

An FDA-approved immunosuppressant with serious risks and unproven longevity use in healthy people.

rapamycin · Rapamune

An experimental exercise-mimetic compound studied in cells and mice.

A food-derived polyamine linked to autophagy biology, with a negative phase 2 cognitive primary outcome.

dietary spermidine · polyamine

An investigational glucagon/GLP-1 dual agonist in Phase 3 research for obesity and metabolic liver disease.

BI 456906

A common nutrient-related molecule whose animal longevity story is challenged by human aging data.

2-aminoethanesulfonic acid

An FDA-approved GLP-2 analog that improves intestinal absorption in short bowel syndrome dependent on parenteral support.

Gattex · Revestive · GLP-2 analog

A growth hormone-releasing factor analog approved for a narrow HIV-related indication.

Egrifta SV

An immune-modulating peptide used in some countries but not FDA approved for any U.S. indication.

Tα1 · thymalfasin · Zadaxin

A naturally occurring peptide studied in tissue repair; marketed fragments are not FDA approved.

Tβ4 · TB4 · full-length thymosin beta-4 · TB-500 (fragment marketed online)

A dual GIP/GLP-1 receptor agonist approved for specific metabolic and sleep-apnea uses.

Mounjaro · Zepbound

An FDA-approved synthetic peptide analog for Rett syndrome with modest trial benefits and frequent gastrointestinal adverse effects.

Daybue · NNZ-2566

A mitophagy-related metabolite with human biomarker and muscle-endurance signals but no approved disease use.

UA · pomegranate-derived postbiotic

A C-type natriuretic peptide analog approved to increase growth in children with achondroplasia.

Voxzogo

A cone-snail-inspired peptide medicine approved for severe chronic pain under specialist care.

Prialt · SNX-111